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PPAR-alpha agonists [ edit] An endogenous compound, 7 (S)-Hydroxydocosahexaenoic Acid (7 (S)-HDHA), which is a Docosanoid derivative of the omega-3 fatty acid DHA was isolated as an endogenous high affinity ligand for PPAR-alpha in the rat and mouse brain. The 7 (S) enantiomer bound with micromolar affity to PPAR alpha with 10 fold higher ...
In the field of molecular biology, the peroxisome proliferator–activated receptors ( PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. [1] PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism ( carbohydrate, lipid, protein ...
View/Edit Mouse. Peroxisome proliferator-activated receptor alpha ( PPAR-α ), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene. [5] Together with peroxisome proliferator-activated receptor delta and peroxisome ...
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View/Edit Mouse. Peroxisome proliferator-activated receptor delta (PPAR-delta), or (PPAR-beta), also known as Nuclear hormone receptor 1 (NUC1) is a nuclear receptor that in humans is encoded by the PPARD gene. [5] This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. It was first identified in Xenopus in 1993.
T3 or T3R - Tier 3 or Tier 3 Reinvestigation, now replace all NACLC. T5 and T5R - Tier 5 or Tier 5 Reinvestigation, now replace SSBI and SBPR respectively. Yankee White – An investigation required for personnel working with the President and Vice President of the United States. Obtaining such clearance requires, in part, an SSBI.