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The intravenous dose causing 50% of opioid-naive experimental subjects to die (LD 50) is "3 mg/kg in rats, 1 mg/kg in cats, 14 mg/kg in dogs, and 0.03 mg/kg in monkeys." [ 96 ] The LD 50 in mice has been given as 6.9 mg/kg by intravenous administration, 17.5 mg/kg intraperitoneally, 27.8 mg/kg by oral administration. [ 97 ]
Believed to be the first coupon ever, this ticket for a free glass of Coca-Cola was first distributed in 1888 to help promote the drink. By 1913, the company had redeemed 8.5 million tickets. [6] Coca-Cola's 1888-issued "free glass of" is the earliest documented coupon. [6] [7] Coupons were mailed to potential customers and placed in magazines ...
Members also get a free dessert or appetizer when they visit during their birthday month. $5 Happy Hour Deals P.F. Chang’s features a full bar, and it has launched an All Day Every Day Happy ...
Amazon websites are country-specific (for example, amazon.com for the US and amazon.co.uk for UK) though some offer international shipping. [48] Visits to amazon.com grew from 615 million annual visitors in 2008, [49] to more than 2 billion per month in 2022. [citation needed] The e-commerce platform is the 14th most visited website in the ...
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