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In the field of molecular biology, the peroxisome proliferator–activated receptors ( PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. [1] PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism ( carbohydrate, lipid, protein ...
View/Edit Mouse. Peroxisome proliferator-activated receptor alpha ( PPAR-α ), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene. [5] Together with peroxisome proliferator-activated receptor delta and peroxisome ...
PPAR-gamma agonists. PPARγ (gamma) is the main target of the drug class of thiazolidinediones (TZDs), used in diabetes mellitus and other diseases that feature insulin resistance. It is also mildly activated by certain NSAIDs (such as ibuprofen) and indoles, as well as from a number of natural compounds.
View/Edit Mouse. Peroxisome proliferator-activated receptor delta (PPAR-delta), or (PPAR-beta), also known as Nuclear hormone receptor 1 (NUC1) is a nuclear receptor that in humans is encoded by the PPARD gene. [5] This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. It was first identified in Xenopus in 1993.
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Delta purchased the aircraft at a steep discount: $19.6m each, well below their $33.2m production cost, which led Boeing to accuse the company of dumping the aircraft. Delta would later increase its order to a total of 145 A220 aircraft. For its wide-body fleet, Delta acquired 25 Airbus A330neo and 42 of the newly introduced Airbus A350 ...
Background. Riley Testut started developing GBA4iOS, the predecessor of Delta, during his senior year at Richardson High School along with his friend Paul Thorsen. It was a emulator of the Game Boy Advance for the iPhone. iOS users had to sideload the emulator via a loophole called the "Date Trick", where the app is allowed to be downloaded and installed via the Safari browser, without needing ...
Pattern recognition receptors ( PRRs) [1] play a crucial role in the proper function of the innate immune system. PRRs are germline-encoded host sensors, which detect molecules typical for the pathogens. [2] They are proteins expressed mainly by cells of the innate immune system, such as dendritic cells, macrophages, monocytes, neutrophils, as ...
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