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Ethanol is the oldest known sedative, used as an oral general anesthetic during surgery in ancient Mesopotamia and in medieval times. [16] [17] Mild intoxication starts at a blood alcohol concentration of 0.03-0.05 % and induces anesthetic coma at 0.4%. [25] However, this use carried the high risk of deadly alcohol intoxication and pulmonary ...
In finance, a coupon is the interest payment received by a bondholder from the date of issuance until the date of maturity of a bond . Coupons are normally described in terms of the "coupon rate", which is calculated by adding the sum of coupons paid per year and dividing it by the bond's face value. For example, if a bond has a face value of ...
Lexington is the second-most-populous city in the Commonwealth of Kentucky (after Louisville ), and the 60th-most populous city in the United States. It is the county seat of Fayette County. By land area, it is the country's 30th-largest city . Lexington is known as the "Horse Capital of the World". It is within the state's Bluegrass region.
California's economy is the largest of any US state, with a $3.6 trillion gross state product as of 2022. It is the largest sub-national economy in the world. California's agricultural industry has the highest output of any U.S. state, [21] [22] [23] and is led by its dairy , almonds , and grapes . [24]
Off-label use. Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration. [1] Both prescription drugs and over-the-counter drugs (OTCs) can be used in off-label ways, although most studies of off-label use focus on prescription drugs.
The United States home front during World War II supported the war effort in many ways, including a wide range of volunteer efforts and submitting to government-managed rationing and price controls. There was a general feeling of agreement that the sacrifices were for the national good during the war. The labor market changed radically.