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An endogenous compound, 7(S)-Hydroxydocosahexaenoic Acid (7(S)-HDHA), which is a Docosanoid derivative of the omega-3 fatty acid DHA was isolated as an endogenous high affinity ligand for PPAR-alpha in the rat and mouse brain.
PPAR-α is primarily activated through ligand binding. Endogenous ligands include fatty acids such as arachidonic acid as well as other polyunsaturated fatty acids and various fatty acid-derived compounds such as certain members of the 15-hydroxyeicosatetraenoic acid family of arachidonic acid metabolites, e.g. 15(S)-HETE, 15(R)-HETE, and 15(S)-HpETE and 13-hydroxyoctadecadienoic acid, a ...
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Seladelpar is indicated for the treatment of primary biliary cholangitis in combination with ursodeoxycholic acid in adults who have an inadequate response to ursodeoxycholic acid, or as monotherapy in people unable to tolerate ursodeoxycholic acid.
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Gmail is the email service provided by Google.As of 2019, it had 1.5 billion active users worldwide, making it the largest email service in the world. [1] It also provides a webmail interface, accessible through a web browser, and is also accessible through the official mobile application.
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Security clearances can be issued by many United States of America government agencies, including the Department of Defense (DoD), the Department of State (DOS), the Department of Homeland Security (DHS), the Department of Energy (DoE), the Department of Justice (DoJ), the National Security Agency (NSA), and the Central Intelligence Agency (CIA).